Bugün 03 Ağustos 2026 Pazartesi

TÜRKİYE PROBİYOTİK REHBERİ

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Ticari Marka Probiyotik Mikroorganizma İçeriği Ticari Form KOB (CFU) Günlük Önerilen Kullanım Miktarı Yaş/Cinsiyet Kaynağa Dayalı Destek Kullanım Alanı-Kaynağa Göre Kanıt Düzeyi
Kaynağa Dayalı Destek Kullanım Alanları
Destek Alanı Seviye Kaynak
İBS (İritable Bağırsak Sendromu) 1 Kim HJ, Camilleri M, McKinzie S, Lempke MB, Burton DD, Thomforde GM, Zinsmeister AR. A randomized controlled trial of VSL#3 formulation in patients with irritable bowel syndrome with bloating. Am J Gastroenterol. 2003 Apr;98(4):869-74. doi: 10.1016/S0002-9270(03)00044-0. PMID: 12656692.
İBS (İritable Bağırsak Sendromu) 1 Kim HJ, Vazquez Roque MI, Camilleri M, Stephens D, Burton DD, Baxter K, Thomforde G, Zinsmeister AR. A randomized controlled trial of a probiotic combination VSL#3 and placebo in irritable bowel syndrome with bloating. Neurogastroenterol Motil. 2005 Oct;17(5):687-96. doi: 10.1111/j.1365-2982.2005.00695.x. PMID: 16185307.
Ülseratif Kolit 1 Sood A, Midha V, Makharia GK, Ahuja V, Singal D, Goswami P, Tandon RK. The probiotic preparation, VSL#3 induces remission in patients with mild-to-moderately active ulcerative colitis. Clin Gastroenterol Hepatol. 2009 Nov;7(11):1202-9, 1209.e1. doi: 10.1016/j.cgh.2009.07.016. Epub 2009 Jul 22. PMID: 19631292.
Ülseratif Kolit 1 Tursi A, Brandimarte G, Papa A, Giglio A, Elisei W, Giorgetti GM, Forti G, Morini S, Hassan C, Pistoia MA, Modeo ME, Rodino' S, D'Amico T, Sebkova L, Sacca' N, Di Giulio E, Luzza F, Imeneo M, Larussa T, Di Rosa S, Annese V, Danese S, Gasbarrini A. Treatment of relapsing mild-to-moderate ulcerative colitis with the probiotic VSL#3 as additive to a standard pharmaceutical treatment: a double-blind, randomized, placebo-controlled study. Am J Gastroenterol. 2010 Oct;105(10):2218-27. doi: 10.1038/ajg.2010.218. Epub 2010 Jun 1. PMID: 20517305; PMCID: PMC3180711.
Hepatik ensefalopati profilaksi 1 Agrawal A, Sharma BC, Sharma P, Sarin SK. Secondary prophylaxis of hepatic encephalopathy in cirrhosis: an open-label, randomized controlled trial of lactulose, probiotics, and no therapy. Am J Gastroenterol. 2012 Jul;107(7):1043-50. doi: 10.1038/ajg.2012.113. Epub 2012 Jun 19. PMID: 22710579.
Hepatik ensefalopati profilaksi 1 Lunia MK, Sharma BC, Sharma P, Sachdeva S, Srivastava S. Probiotics prevent hepatic encephalopathy in patients with cirrhosis: a randomized controlled trial. Clin Gastroenterol Hepatol. 2014 Jun;12(6):1003-8.e1. doi: 10.1016/j.cgh.2013.11.006. Epub 2013 Nov 15. PMID: 24246768.
Poşit 1 Bacterial and fungal microbiota in relation to probiotic therapy (VSL#3) in pouchitis V Kühbacher, S J Oti, U Helwig, T Mimura, F Rizzello, B Kleessen, P Gionchetti, M Blaut, M Campieri, U R Fölsch, M A Kamm, S Schreiber Gut. 2006 Jun; 55(6): 833–841. doi: 10.1136/gut.2005.078030. PMCID: PMC1856240
Poşit 1 Kamm MA. One daily high dose probiotic therapy (VSL#3) for maintaining remission in recurrent or refractory pouchitis. Gut. 2004 Jan;53(1):108-14. doi: 10.1136/gut.53.1.108. PMID: 14684584; PMCID: PMC1773918.
Kaynağa Dayalı Destek Kullanım Alanları
Destek Alanı Seviye Kaynak
Ülseratif Kolit 1 Huynh HQ, deBruyn J, Guan L, Diaz H, Li M, Girgis S, Turner J, Fedorak R, Madsen K. Probiotic preparation VSL#3 induces remission in pediatric patients with mild-to-moderate ulcerative colitis: a pilot study. Inflamm Bowel Dis. 2009 May;15(5):760-8. doi: 10.1002/ibd.20816. PMID: 19067432.
Ülseratif Kolit 1 Miele E, Pascarella F, Giannetti E, Quaglietta L, Baldassano RN, Staiano A. Effect of a probiotic preparation (VSL#3) on induction and maintenance of remission in children with ulcerative colitis. Am J Gastroenterol. 2009 Feb;104(2):437-43. doi: 10.1038/ajg.2008.118. Epub 2009 Jan 20. PMID: 19174792.
Kaynağa Dayalı Destek Kullanım Alanları
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Metabolizma ve Obezite Destek Tedavisi 3 Stenman LK, Lehtinen MJ, Meland N, Christensen JE, Yeung N, Saarinen MT, Courtney M, Burcelin R, Lähdeaho ML, Linros J, Apter D, Scheinin M, Kloster Smerud H, Rissanen A, Lahtinen S. Probiotic With or Without Fiber Controls Body Fat Mass, Associated With Serum Zonulin, in Overweight and Obese Adults-Randomized Controlled Trial. EBioMedicine. 2016 Nov;13:190-200. doi: 10.1016/j.ebiom.2016.10.036. Epub 2016 Oct 26. PMID: 27810310; PMCID: PMC5264483.
Bağırsağın dengesini ve florasını korumak 1
Kaynağa Dayalı Destek Kullanım Alanları
Destek Alanı Seviye Kaynak
Üst solunum yolu enfeksiyonlarında ve soğuk algınlığında destek 1 105- Latvala, S.; Turner, R.; Hibberd, A.; Lehtoranta, L.; Stahl, B.; Lehtinen, M. (2017) Effect of Probiotic Bifidobacterium lactis BL-04 on Host Responses and Microbiota in Experimental Rhinovirus Infection in Healthy Adults. Paper presented at the International Scientific Conference on Probiotics and Prebiotics, Budapest (p. 37). IPC2017
Kaynağa Dayalı Destek Kullanım Alanları
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İBS (İritable Bağırsak Sendromu) 1 108- Spiller, R.; Pelerin, F.; Decherf, A.C.; Maudet, C.; Housez, B.; Cazalsbiel, M.; Jüsten, P. (2016) Randomized Double Blind Placebo-controlled Trial of Saccharomyces cerevisiae CNCM I-3856 in Irritable Bowel Syndrome: Improvement in Abdominal Pain and Bloating in Those with Predominant Constipation. United European Gastroenterology Journal, 4(3), 353-362.
Gastrointestinal sistem desteği 1 108- Spiller, R.; Pelerin, F.; Decherf, A.C.; Maudet, C.; Housez, B.; Cazalsbiel, M.; Jüsten, P. (2016) Randomized Double Blind Placebo-controlled Trial of Saccharomyces cerevisiae CNCM I-3856 in Irritable Bowel Syndrome: Improvement in Abdominal Pain and Bloating in Those with Predominant Constipation. United European Gastroenterology Journal, 4(3), 353-362.
İBS (İritable Bağırsak Sendromu) 1 109- de Chambrun, G.P.; Neut, C.; Chau, A.; Cazaubiel, M.; Pelerin, F.; Justen, P.; Desreumaux, P. (2015) A Randomized Clinical Trial of Saccharomyces cerevisiae strain CNCM I-3856 in Irritable Bowel Syndrome: Improvement in Abdominal Pain and Bloating in Those with Predominant Stool Discomfort. Digestive and Liver Disease, 47, 119-124.
Gastrointestinal sistem desteği 1 109- de Chambrun, G.P.; Neut, C.; Chau, A.; Cazaubiel, M.; Pelerin, F.; Justen, P.; Desreumaux, P. (2015) A Randomized Clinical Trial of Saccharomyces cerevisiae strain CNCM I-3856 in Irritable Bowel Syndrome: Improvement in Abdominal Pain and Bloating in Those with Predominant Stool Discomfort. Digestive and Liver Disease, 47, 119-124.
Kaynağa Dayalı Destek Kullanım Alanları
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Vajinal Sağlık Desteği 1 106- Russo, R.; Karadja, E.; De Seta, F. (2019) Evidence-based Mixture Containing Lactobacillus strains and Lactoferrin to Prevent Recurrent Bacterial Vaginosis: A Double Blind, Placebo controlled, Randomised Clinical Trial. Beneficial Microbes, 10(1) 19-26.
Bakteriyel Vajinosis 1 106- Russo, R.; Karadja, E.; De Seta, F. (2019) Evidence-based Mixture Containing Lactobacillus strains and Lactoferrin to Prevent Recurrent Bacterial Vaginosis: A Double Blind, Placebo controlled, Randomised Clinical Trial. Beneficial Microbes, 10(1) 19-26.
Vajinal Sağlık Desteği 1 107- Russo, R.; Superti, F.; Karadja, E.; De Seta, F. (2018) Randomised Clinical Trial in Women with Recurrent Vulvovaginal Candidiasis: Efficacy of Probiotics and Lactoferrin as Maintenance Treatment. Mycoses, 62,328-335.
Bakteriyel Vajinosis 1 107- Russo, R.; Superti, F.; Karadja, E.; De Seta, F. (2018) Randomised Clinical Trial in Women with Recurrent Vulvovaginal Candidiasis: Efficacy of Probiotics and Lactoferrin as Maintenance Treatment. Mycoses, 62,328-335.
Kaynağa Dayalı Destek Kullanım Alanları
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Antibiyotikle ilişkili GIS sorunlarına destek 1 103- De Wolfe, T. J.; Eggers, S.; Barker, A.K.; Cates, A.E.; Dill-McFarland, K.A.; Suen, G.; Safdar, N. (2018) Oral Probiotic Combination of Lactobacillus and Bifidobacterium Alters the Gastrointestinal Microbiota During Antibiotic Treatment for Clostridium difficile Infection. PLoS One, 13(9), e0204253.
Gastrointestinal sistem desteği 1 104- Barker, A.K.; Duster, M.; Valentine, S.; Hess, T.; Archbald-Pannone, L.; Guerrant, R.; Safdar, N. (2017) A Randomized Controlled Trial of Probiotics for Clostridium difficile Infection in Adults (PICO). J. Antimicrob Chemother, 72, 3177-3180.