Bugün 03 Ağustos 2026 Pazartesi

TÜRKİYE PROBİYOTİK REHBERİ

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Ticari Marka Probiyotik Mikroorganizma İçeriği Ticari Form KOB (CFU) Günlük Önerilen Kullanım Miktarı Yaş/Cinsiyet Kaynağa Dayalı Destek Kullanım Alanı-Kaynağa Göre Kanıt Düzeyi
Kaynağa Dayalı Destek Kullanım Alanları
Destek Alanı Seviye Kaynak
Sindirim sistemini düzenleyerek bağışıklık sistemini desteklemek T.C. TARIM VE ORMAN BAKANLIĞI PMOL listesi kapsamındadır
Kaynağa Dayalı Destek Kullanım Alanları
Destek Alanı Seviye Kaynak
Sindirim sistemini düzenleyerek bağışıklık sistemini desteklemek T.C. TARIM VE ORMAN BAKANLIĞI PMOL listesi kapsamındadır
Kaynağa Dayalı Destek Kullanım Alanları
Destek Alanı Seviye Kaynak
Ürogenital Sistem Enfeksiyonu 1 2-Hummelen, R.; Changalucha, J.; Butamanya, N.L.; Cook, J.D.F.; Habbema, J.D.; Reid, G. (2010) Lactobacillus rhamnosus GR-1 and L reuteri RC-14 to Prevent or Cure Bacterial Vaginosis Among Women with HIV. International Journal of Gynecology & Obstetrics, 111(3), 245-248.
Ürogenital Sistem Enfeksiyonu 1 3-Reid, G.; Bruce, A.W.; Fraser, N.; Heinemann, C.; Owen, J.; Henning, B. (2001) Oral Probiotics Can Resolve Urogenital Infections. FEMS Immunology & Medical Microbiology, 30(1), 49-52.
Ürogenital Sistem Enfeksiyonu 1 4-Anukam, K.; Osazuwa, E.; Ahonkhai, I.; Ngwu, M.; Osemene, G.I.; Bruce, A.W.; Reid, G. (2006) Augmentation of Antimicrobial Metronidazole Therapy of Bacterial Vaginosis with Oral Probiotic Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14: Randomized, Double-blind, Placebo Controlled Trial. Microbes and Infection, 8(6), 1450-1454.
Ürogenital Sistem Enfeksiyonu 1 1-Anukam, K.C.; Osazuwa, E.O.; Osemene, G.I.; Ehigiagbe, F.; Bruce, A.W.; Reid, G. (2006) Clinical Study Comparing Probiotic Lactobacillus GR-1 and RC-14 with Metronidazole Vaginal Gel to Treat Symptomatic Bacterial Vaginosis. Microbes and Infection, 8(12), 2772-2776.
Vajinal Flora Restorasyonu 1 57- Reid, G.; D. Charbonneau, J.; Erb, B.; Kochanowski, D.; Beuerman, R.; Poehner, and A.W. Bruce. (2003) Oral Use of Lactobacillus rhamnosus GR-1 and L. ferrnenturn RC-14 Significantly Alters Vaginal Flora: Randomized, Placebo-controlled Trial in 64 Healthy Women. FEMS Immunology & Medical Microbiology, 35.2, 131-134.
Ürogenital Sistem Enfeksiyonu 1 6-Vujic, G.; Knez, A.J.; Stefanovic, V.D.; Vrbanovic, V.K. (2013) Efficacy of Orally Applied Probiotic Capsules for Bacterial Vaginosis and Other Vaginal Infections: A Double-blind, Randomized, Placebo-controlled Study. European Journal of Obstetrics & Gynecology and Reproductive Biology, 168(1), 75-79.
Ürogenital Sistem Enfeksiyonu 1 5-Martinez, R.C.; Franceschini, S.A.; Patta, M.C.; Quintana, S.M.; Gomes, B.C.; De Martinis, E.C.; Reid, G. (2009) Improved Cure of Bacterial Vaginosis with Single Dose of Tinidazole (2 g), Lactobacillus rhamnosus GR-1, and Lactobacillus reuteri RC-14: A Randomized, Double-blind, Placebo-controlled Trial. Canadian Journal of Microbiology, 55(2), 133-138.
Vajinal Flora Restorasyonu 1 7-Martinez, R.C.; Franceschini, S.A.; Patta, M.C.; Quintana, S.M.; Candido, R.C.; Ferreira, J.C.; De Martinis, E.C.; Reid, G. (2009) Improved Treatment of Vulvovaginal Candidiasis with Fluconazole Plus Probiotic Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14. Letters in Applied Microbiology, 48(3), 269-274.
Kaynağa Dayalı Destek Kullanım Alanları
Destek Alanı Seviye Kaynak
İBS (İritable Bağırsak Sendromu) 1 Benes, K., A. Kretk, and Thomas A. Tompkins. "A probiotic combination for IBS. Apilot clinical study." NutraFoods 5.1 (2006): 20-27 (3) Diop et al. 2008. Nutrition Research Volume 28, Issue 1, January 2008. Pages 1-5.
Stres 1 1-Diop, L.; Guillou, S.; Durand, H. (2007) Probiotic Food Supplement Reduces Stress-induced Gastrointestinal Symptoms in Volunteers: A Double-blind, placebo-controlled, Randomized Trial. Nutr Res, 28(1), 1-5.
Anksiyete 1 53- Messaoudi, M.; Violle, N.; Bisson, JF.; Desor, D.; Javelot, H.; Rougeot, C. (2011) Beneficial Psychological Effects of A Probiotic Formulation Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in Healthy Human Volunteers.
Stres 1 2-Messaoudi, M.; Lalonde, R.; Violle, N.; Javelot, H.; Desor, D.; Nejdi, A.; Bisson, JF.; Rougeot, C.; Pichelin, M.; Cazaubiel, M.; Cazaubiel, JM. (2011) Assessment of Psychotropic-like Properties of a Probiotic Formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in Rats and Human Subjects. Br J Nutr, 105(5), 755-764.
Kaynağa Dayalı Destek Kullanım Alanları
Destek Alanı Seviye Kaynak
Ülseratif Kolit 1 Double-blind comparison of an oral Escherichia coli preparation and mesalazine in maintaining remission of ulcerative colitis W Kruis 1, E Schütz, P Fric, B Fixa, G Judmaier, M Stolte
Sindirim sistemini düzenlemek 1 Maintaining remission of ulcerative colitis with the probiotic Escherichia coli Nissle 1917 is as effective as with standard mesalazine
Ülseratif Kolit 1 Maintaining remission of ulcerative colitis with the probiotic Escherichia coli Nissle 1917 is as effective as with standard mesalazine W Kruis 1, P Fric, J Pokrotnieks, M Luda's", B Fixa, M Kas'c'a'k, M A Kamm, J Weismueller, C Beglinger, M Stolte, C Wolff, J Schulze
Ülseratif Kolit 1 Probiotic Escherichia coli Nissle 1917 (EcN) for Successful Remission Maintenance of Ulcerative Colitis in Children and Adolescents: an Open-Label Pilot Study J Henker , S Müller , M W Laass , A Schreiner , J Schulze
Ülseratif Kolit 1 Non-pathogenic Escherichia coli versus mesalazine for the treatment of ulcerative colitis: a randomised trial B J Rembacken, A M Snelling, P M Hawkey, D M Chalmers, A T R Axon
Kaynağa Dayalı Destek Kullanım Alanları
Destek Alanı Seviye Kaynak
Sindirim sistemini düzenleyerek bağışıklık sistemini desteklemek T.C. TARIM VE ORMAN BAKANLIĞI PMOL listesi kapsamındadır
Kaynağa Dayalı Destek Kullanım Alanları
Destek Alanı Seviye Kaynak
Sindirim sistemini düzenleyerek bağışıklık sistemini desteklemek 2 Güncelleniyor
Antibiyotik kullanımından kaynaklanan diyare gibi sindirim sistemi bozukluklarının önlenmesi ve tedavisi 1 Mazza, P. (1994) The Use of Bacillus subtilis as an Antidiarrhoeal Microorganism. Boll Chim Farm, 133(1), 3-18.
Bebeklerdeki akut ve kronik gastrointestinal bozukluklar 1 Lahiri, K.; Jadhav, K.; Gahlowt, P.; Najmuddin, F. (2015) Bacillus Clausii 1 As An Adjuvant Therapy In Acute Childhood Diarrhoea. Journal of Dental and Medical Sciences, 14(5), 74-76.
Kaynağa Dayalı Destek Kullanım Alanları
Destek Alanı Seviye Kaynak
Sindirim sistemini düzenleyerek bağışıklık sistemini desteklemek 2 Güncelleniyor
Antibiyotik kullanımından kaynaklanan diyare gibi sindirim sistemi bozukluklarının önlenmesi ve tedavisi 1 Mazza, P. (1994) The Use of Bacillus subtilis as an Antidiarrhoeal Microorganism. Boll Chim Farm, 133(1), 3-18.
Bebeklerdeki akut ve kronik gastrointestinal bozukluklar 1 Lahiri, K.; Jadhav, K.; Gahlowt, P.; Najmuddin, F. (2015) Bacillus Clausii 1 As An Adjuvant Therapy In Acute Childhood Diarrhoea. Journal of Dental and Medical Sciences, 14(5), 74-76.
Kaynağa Dayalı Destek Kullanım Alanları
Destek Alanı Seviye Kaynak
Antibiyotik tedavisine bağlı diyare 1 Cremonini F, Di Caro S, Covino M, Armuzzi A, Gabrielli M, Santarelli L, Nista EC, Cammarota G, Gasbarrini G, Gasbarrini A. Effect of different probiotic preparations on anti-helicobacter pylori therapy-related side effects: a parallel group, triple blind, placebo-controlled study. Am J Gastroenterol. 2002 Nov;97(11):2744-9. doi: 10.1111/j.1572-0241.2002.07063.x. PMID: 12425542.
Helicobacter pylori 1 Armuzzi A, Cremonini F, Bartolozzi F, Canducci F, Candelli M, Ojetti V, Cammarota G, Anti M, De Lorenzo A, Pola P, Gasbarrini G, Gasbarrini A. The effect of oral administration of Lactobacillus GG on antibiotic-associated gastrointestinal side-effects during Helicobacter pylori eradication therapy. Aliment Pharmacol Ther. 2001 Feb;15(2):163-9. doi: 10.1046/j.1365-2036.2001.00923.x. PMID: 11148433.
İmmün sistemi desteklemek 1 Rizzardini G, Eskesen D, Calder PC, Capetti A, Jespersen L, Clerici M. Evaluation of the immune benefits of two probiotic strains Bifidobacterium animalis ssp. lactis, BB-12® and Lactobacillus paracasei ssp. paracasei, L. casei 431® in an immunization model: a randomised, double-blind, placebo-controlled study. Br J Nutr. 2012 Sep 7:1-8. PMID: 21899798.
Seyahate bağlı turist diyaresinin önlenmesi ve tedavisi 1 Hilton E, Kolakowski P, Singer C, Smith M. Efficacy of Lactobacillus GG as a Diarrheal Preventive in Travelers. J Travel Med. 1997 Mar 1;4(1):41-43. doi: 10.1111/j.1708-8305.1997.tb00772.x. PMID: 9815476.
Antibiyotik tedavisine bağlı diyare 1 Goran Hauser, Nermin Salkic, Karina Vukelic, Alenka JajacKnez, Davor Stimac Probiotics for Standard Triple Helicobacter pylori Eradication: A Randomized, Double-blind, Placebo-controlled Trial Aliment Pharmacol Ther. 2015 Nov;42(10):1149-57. EBL-05. Published online 2015 May 1. doi: 10.1097/MD.0000000000000685 PMCID: PMC4603068
Helicobacter pylori 1 Goran Hauser, Nermin Salkic, Karina Vukelic, Alenka JajacKnez, Davor Stimac Probiotics for Standard Triple Helicobacter pylori Eradication: A Randomized, Double-blind, Placebo-controlled Trial Aliment Pharmacol Ther. 2015 Nov;42(10):1149-57. EBL-05. Published online 2015 May 1. doi: 10.1097/MD.0000000000000685 PMCID: PMC4603068
İmmün sistemi desteklemek 1 Smith TJ, Rigassio-Radler D, Denmark R, Haley T, Touger-Decker R. Effect of Lactobacillus rhamnosus LGG and Bifidobacterium animalis ssp. lactis BB-12® on health-related quality of life in college students affected by upper respiratory infections. Br J Nutr. 2013 Jun;109(11):1999-2007. doi: 10.1017/S0007114512004138. Epub 2012 Oct 1. PMID: 23020819.
Seyahate bağlı turist diyaresinin önlenmesi ve tedavisi 1 Oksanen PJ, Salminen S, Saxelin M, Hämäläinen P, Ihantola-Vormisto A, Muurasniemi-Isovita L, Nikkari S, Oksanen T, Pörsti L, Salminen E, et al. Prevention of travellers' diarrhoea by Lactobacillus GG. Ann Med. 1990 Feb;22(1):53-6. doi: 10.3109/07853899009147242. PMID: 2184847.
Kaynağa Dayalı Destek Kullanım Alanları
Destek Alanı Seviye Kaynak
Antibiyotik tedavisine bağlı diyare 1 Cremonini F, Di Caro S, Covino M, Armuzzi A, Gabrielli M, Santarelli L, Nista EC, Cammarota G, Gasbarrini G, Gasbarrini A. Effect of different probiotic preparations on anti-helicobacter pylori therapy-related side effects: a parallel group, triple blind, placebo-controlled study. Am J Gastroenterol. 2002 Nov;97(11):2744-9. doi: 10.1111/j.1572-0241.2002.07063.x. PMID: 12425542.
İmmün sistemi desteklemek 1 Hatakka K, Savilahti E, Pönkä A, Meurman JH, Poussa T, Näse L, Saxelin M, Korpela R. Effect of long term consumption of probiotic milk on infections in children attending day care centres: a randomised, double blind trial. BMJ. 2001 Jun 2;322(7298):1327-30. doi: 10.1136/bmj.322.7298.1327. PMID: 11387176; PMCID: PMC32161.
Nozokimyasal diyare 1 Hojsak I, Szajewska H, Canani RB, Guarino A, Indrio F, Kolacek S, Orel R, Shamir R, Vandenplas Y, van Goudoever JB, Weizman Z; ESPGHAN Working Group for Probiotics/Prebiotics. Probiotics for the Prevention of Nosocomial Diarrhea in Children. J Pediatr Gastroenterol Nutr. 2018 Jan;66(1):3-9. doi: 10.1097/MPG.0000000000001687. PMID: 28574970.
Karın Ağrısı 1 Szajewska H, Kotowska M, Mrukowicz JZ, Armarska M, Mikolajczyk W. Efficacy of Lactobacillus GG in prevention of nosocomial diarrhea in infants. J Pediatr. 2001 Mar;138(3):361-5. doi: 10.1067/mpd.2001.111321. PMID: 11241043.
Akut Gastroenterit 1 Aggarwal S, Upadhyay A, Shah D, Teotia N, Agarwal A, Jaiswal V. Lactobacillus GG for treatment of acute childhood diarrhoea: an open labelled, randomized controlled trial. Indian J Med Res. 2014 Mar;139(3):379-85. PMID: 24820831; PMCID: PMC4069731.
Antibiyotik tedavisine bağlı diyare 1 Goran Hauser, Nermin Salkic, Karina Vukelic, Alenka JajacKnez, Davor Stimac Probiotics for Standard Triple Helicobacter pylori Eradication: A Randomized, Double-blind, Placebo-controlled Trial Aliment Pharmacol Ther. 2015 Nov;42(10):1149-57. EBL-05. Published online 2015 May 1. doi: 10.1097/MD.0000000000000685 PMCID: PMC4603068
İmmün sistemi desteklemek 1 Hojsak I, Snovak N, Abdović S, Szajewska H, Misak Z, Kolacek S. Lactobacillus GG in the prevention of gastrointestinal and respiratory tract infections in children who attend day care centers: a randomized, double-blind, placebo-controlled trial. Pediatrics. 2010 Mar;125(5):e1171-7. doi: 10.1542/peds.2009-2458. Epub 2010 Apr 19. PMID: 20403930.
Nozokimyasal diyare 1 Hojsak I, Abdović S, Szajewska H, Milosević M, Krznarić Z, Kolacek S. Lactobacillus GG in the prevention of nosocomial gastrointestinal and respiratory tract infections in pediatric patients. Paediatr Drugs. 2012 May;125(5):e1171-7. doi: 10.1542/peds.2009-2458. Epub 2010 Apr 19. PMID: 20403940.
Karın Ağrısı 1 Francavilla R, Miniello V, Magistà AM, De Canio A, Bucci N, Gagliardi F, Lionetti E, Castellaneta S, Polimeno L, Pezzolla L, Indrio F, Cavallo L, Ierardi E, Cucchiara S. A randomized controlled trial of Lactobacillus GG in children with functional abdominal pain. Pediatrics. 2010 Dec;126(6):e1445-52. doi: 10.1542/peds.2010-0467. Epub 2010 Nov 15. PMID: 21078735.
Akut Gastroenterit 1 Dinleyici, E., Özen, M., Dalgıç, N., Yasa, O., Anca, N., Vetr, M., Tanır, O., Kurugöl, Z., Güven, Ş., Yazar, A., Karbuz, A., Naibantoğlu, B., Sancar, M., Eren, M., Kara, A., Vandenplas, Y. (2020). Effect of Lactobacillus rhamnosus GG and Bifidobacterium animalis subspecies lactis BB-12 combination on duration of diarrhea and length of hospital stay in children with acute diarrhea in Turkey . Mucosa , 3 (2) , 34-41 . DOI: 10.33204/mucosa.738326
Kaynağa Dayalı Destek Kullanım Alanları
Destek Alanı Seviye Kaynak
İnfantil Kolik 1 Nocerino R, De Filippis F, Cecere G, Marino A, Micillo M, Di Scala C, de Caro C, Calignano A, Bruno C, Paparo L, Ianncelli AM, Cosenza L, Maddalena Y, Della Gatta G, Coppola S, Carucci L, Ercolini D, Berni Canani R. The therapeutic efficacy of Bifidobacterium lactis subsp. lactis BB-12® in infant colic: A randomized, double blind, placebo-controlled trial. Aliment Pharmacol Ther. 2020 Jan;51(1):110-120. doi: 10.1111/apt.15561. Epub 2019 Dec 3. PMID: 31797399; PMCID: PMC6973258.
Akut Gastroenterit 1 Aggarwal S, Upadhyay A, Shah D, Teotia N, Agarwal A, Jaiswal V. Lactobacillus GG for treatment of acute childhood diarrhoea: an open labelled, randomized controlled trial. Indian J Med Res. 2014 Mar;139(3):379-85. PMID: 24820831; PMCID: PMC4069731.
İnfantil Kolik 1 Anna Pärtty, Raakel Luoto, Marko Kalliomäki, Seppo Salminen, Erika Isolauri, Effects of early Prebiotic and Probiotic Supplementation on Development of Gut Microbiota and Fussing and Crying in Preterm Infants: A Randomized, Double-Blind, Placebo-Controlled Trial, The Journal of Pediatrics,Volume 163, Issue 5,2013,Pages 1272-1277.e2, ISSN 0022-3476.
Akut Gastroenterit 1 Dinleyici, E., Özen, M., Dalgıç, N., Yasa, O., Anca, N., Vetr, M., Tanır, O., Kurugöl, Z., Güven, Ş., Yazar, A., Karbuz, A., Naibantoğlu, B., Sancar, M., Eren, M., Kara, A., Vandenplas, Y. (2020). Effect of Lactobacillus rhamnosus GG and Bifidobacterium animalis subspecies lactis BB-12 combination on duration of diarrhea and length of hospital stay in children with acute diarrhea in Turkey . Mucosa , 3 (2) , 34-41 . DOI: 10.33204/mucosa.738326
Kaynağa Dayalı Destek Kullanım Alanları
Destek Alanı Seviye Kaynak
Sindirim sistemini düzenleyerek bağışıklık sistemini desteklemek T.C. TARIM VE ORMAN BAKANLIĞI PMOL listesi kapsamındadır